Flexible and Intelligent Learning Architectures for SOS (FILA-SoS)

Multi-faceted systems of the future will entail complex logic and reasoning with many levels of reasoning in intricate arrangement. The organization of these systems involves a web of connections and demonstrates self-driven adaptability. They are designed for autonomy and may exhibit emergent behavior that can be visualized. Our quest continues to handle complexities, design and operate these systems. The challenge in Complex Adaptive Systems design is to design an organized complexity that will allow a system to achieve its goals. This report attempts to push the boundaries of research in complexity, by identifying challenges and opportunities. Complex adaptive system-of-systems (CASoS) approach is developed to handle this huge uncertainty in socio-technical systems

An Advanced Computational Approach to System of Systems Analysis & Architecting Using Agent-Based Behavioral Model

A major challenge to the successful planning and evolution of an acknowledged System of Systems (SoS) is the current lack of understanding of the impact that the presence or absence of a set of constituent systems has on the overall SoS capability. Since the candidate elements of a SoS are fully functioning, stand-alone Systems in their own right, they have goals and objectives of their own to satisfy, some of which may compete with those of the overarching SoS. These system-level concerns drive decisions to participate (or not) in the SoS. Individual systems typically must be requested to join the SoS construct, and persuaded to interface and cooperate with other Systems to create the “new” capability of the proposed SoS. Current SoS evolution strategies lack a means for modeling the impact of decisions concerning participation or non-participation of any given set of systems on the overall capability of the SoS construct. Without this capability, it is difficult to optimize the SoS design. The goal of this research is to model the evolution of the architecture of an acknowledged SoS that accounts for the ability and willingness of constituent systems to support the SoS capability development. Since DoD Systems of Systems (SoS) development efforts do not typically follow the normal program acquisition process described in DoDI 5000.02, the Wave Model proposed by Dahmann and Rebovich is used as the basis for this research on SoS capability evolution. The Wave Process Model provides a framework for an agent-based modeling methodology, which is used to abstract the nonutopian behavioral aspects of the constituent systems and their interactions with the SoS. In particular, the research focuses on the impact of individual system behavior on the SoS capability and architecture evolution processes. A generic agent-based model (ABM) skeleton structure is developed to provide an Acknowledged SoS manager a decision making tool in negotiating of SOS architectures during the wave model cycles. The model provides an environment to plug in multiple SoS meta-architecture generation multiple criteria optimization models based on both gradient and non-gradient descent optimization procedures. Three types of individual system optimization models represent different behaviors of systems agents, namely; selfish, opportunistic and cooperative, are developed as plug in models. ABM has a plug in capability to incorporate domain-specific negotiation modes and a fuzzy associative memory (FAM) to evaluate candidate architectures for simulating SoS creation and evolution. The model evaluates the capability of the evolving SoS architecture with respect to four attributes: performance, affordability, flexibility and robustness. In the second phase of the project, the team will continue with the development of an evolutionary strategies-based multi-objective mathematical model for creating an initial SoS meta architecture to start the negotiation at each wave. A basic generic structure will be defined for the fuzzy assessor math model that will be used to evaluate SoS meta architectures and domain dependent parameters pertaining to system of systems analysis and architecting through Agent Based Modeling. The work will be conducted in consideration of the national priorities, funding and threat assessment being provided by the environment developed for delivery at end of December 2013

Synthesis of 5-Hydroxyectoine from Ectoine: Crystal Structure of the Non-Heme Iron(II) and 2-Oxoglutarate-Dependent Dioxygenase EctD

As a response to high osmolality, many microorganisms synthesize various types of compatible solutes. These organic osmolytes aid in offsetting the detrimental effects of low water activity on cell physiology. One of these compatible solutes is ectoine. A sub-group of the ectoine producer's enzymatically convert this tetrahydropyrimidine into a hydroxylated derivative, 5-hydroxyectoine. This compound also functions as an effective osmostress protectant and compatible solute but it possesses properties that differ in several aspects from those of ectoine. The enzyme responsible for ectoine hydroxylation (EctD) is a member of the non-heme iron(II)-containing and 2-oxoglutarate-dependent dioxygenases (EC 1.14.11). These enzymes couple the decarboxylation of 2-oxoglutarate with the formation of a high-energy ferryl-oxo intermediate to catalyze the oxidation of the bound organic substrate. We report here the crystal structure of the ectoine hydroxylase EctD from the moderate halophile Virgibacillus salexigens in complex with Fe3+ at a resolution of 1.85 Å. Like other non-heme iron(II) and 2-oxoglutarate dependent dioxygenases, the core of the EctD structure consists of a double-stranded β-helix forming the main portion of the active-site of the enzyme. The positioning of the iron ligand in the active-site of EctD is mediated by an evolutionarily conserved 2-His-1-carboxylate iron-binding motif. The side chains of the three residues forming this iron-binding site protrude into a deep cavity in the EctD structure that also harbours the 2-oxoglutarate co-substrate-binding site. Database searches revealed a widespread occurrence of EctD-type proteins in members of the Bacteria but only in a single representative of the Archaea, the marine crenarchaeon Nitrosopumilus maritimus. The EctD crystal structure reported here can serve as a template to guide further biochemical and structural studies of this biotechnologically interesting enzyme family

A domain independent method to assess system of system meta-architectures using domain specific fuzzy information

This research proposes a domain independent method to build and assess systems of systems (SoS) architecture models. A simplified meta-architecture containing each component system\u27s participation and a first order, binary, system-to-system interface is proposed. The method describes how to elicit desired SoS attributes from stakeholders. Measures of the attributes depend on systems\u27 participation and interfaces, that is, on the SoS architecture. The goal is to model a realizable SoS configuration, optimized over multiple attributes. Key attribute measures are combined in a fuzzy inference system to assess an overall fitness measure for any SoS in the meta-architecture. A genetic algorithm is used to find \u27good\u27 SoS architectures with a fitness that depends on the participation framework. This research illustrates a method to define architecture sensitive attributes and build the fuzzy assessor. These are two segments of the Missouri S&T developed nine part Flexible Intelligent Learning Architectures for SoS (FILA-SoS) research approach to architecting SoS. A desirable SoS architecture may be handed off to an agent-based model to examine the impact of various negotiation behaviors or policies on realization of the SoS. The final configuration can evolve over several development epochs in the wave model. The method is demonstrated on SoS in several domains to illustrate its broad generality. Two intelligence, surveillance and reconnaissance (ISR) SoS, a search and rescue (SAR) SoS, two versions of the MITRE Toy problem, and an actual SoS for a large training program are analyzed. The method provides researchers and designers with a novel way to think about the effects of imprecise stakeholder desires and acquisition policies on SoS architecting --Abstract, page iii

Piéces concernant l'histoire du XV e siècle.

Contient : 1° Réponse du pape Pie II au roi de Bohême sur la question de la communion sous les deux espèces ; 2° Rapport du F. Louis de Bannoni (Hongrie), sur les princes orientaux prêts à secourir la Chrétienté contre le Turc ; 3° Prédictions astrologiques pour les années 1462 à 1464 ; 4° Prédictions de Théodore de Pouille pour l'an 1463 ; 5° Révélations de Raymundus ; 6° Révélations de Sygwaldus [cancellées] ; 7° Pronostics pour l'an 1422: "Wissent daz wir Johannes der gross naturlich meister zu dieser zeiten… – … in der kristenheit in arabien in franckreich und in yspanien." ; 8° Prédictions astrologiquesNumérisation effectuée à partir d'un document de substitution